Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression of WT KRAS protein.We previously demonstrated that SHP2 phosphatase, which acts to promote KRAS and downstream MAPK pathway activation, is a target in these tumors when combined with MEK inhibition.We hypothesized that SHP2 inhibitors ma
This case report describes an alternative minimally invasive treatment option using 4-mm-long ultrashort implants placed to rehabilitate a severely atrophic edentulous maxilla.The patient, coming from a full removable Dressage Saddle denture, asked for an implant prosthesis avoiding reconstructive surgeries and expensive procedures.Considering that
Atherosclerosis is a complex metabolic disease characterized by the dysfunction of lipid metabolism and chronic inflammation in the intimal space of the vessel.As Ear Care the most abundant innate immune cells, monocyte-derived macrophages play a pivotal role in the inflammatory response, cholesterol metabolism, and foam cell formation.In recent de
The study is focused on the mineralogy of rare-element rich tourmaline-bearing miarolitic pegmatities of the Shakhdarinskaya vein (SW Pamirs, Tajikistan).The results of the study are crucially important for understanding the regularities of distribution and behavior of Li, Rb and Cs in the course of crystallization of the most low-temperature pegma